Secreted frizzled-related protein 2 prevents pressure-overload-induced cardiac hypertrophy by targeting the Wnt/β-catenin pathway
نویسندگان
چکیده
منابع مشابه
Evodiamine attenuates pressure overload-induced cardiac hypertrophy
Evodiamine, a traditional Chinese herb Evodia rutaecarpa, has been shown its anti-inflammatory and anti-bacterial properties. However, the role of evodiamine in cardiac hypertrophy and its possible molecular mechanisms remain unclear. Therefore, this study aimed to investigate the effect of evodiamine on cardiac hypertrophy and explore the possible mechanisms. Aortic banding (AB) on mice was pe...
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To explore the effects of celecoxib on pressure overload-induced cardiac hypertrophy (CH), cardiac dysfunction and explore the possible protective mechanisms. We surgically created abdominal aortic constrictions (AAC) in rats to induce CH. Rats with CH symptoms at 4 weeks after surgery were treated with celecoxib [2 mg/100 g body-weight(BW)] daily for either 2 or 4 weeks. Survival rate, blood p...
متن کاملCardiac hypertrophy and the Wnt/Frizzled pathway.
The heart responds to sustained pressure overload with hypertrophy. Although at first glance this seems to be an adaptive mechanism by which the heart battles against increased workload, there is evidence that these “compensatory changes,” even early in the game, are different from the benign, truly adaptive response that occurs, for example, in athletes.1 In this group, hypertrophy is characte...
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The calcium-responsive molecule, calcineurin, has been well characterized to play a causal role in pathological cardiac hypertrophy over the past decade. However, the intrinsic negative regulation of calcineurin signaling during the progression of cardiomyocyte hypertrophy remains enigmatic. Herein, we explored the role of EPI64C, a dual inhibitor of both Ras and calcineurin signaling during T-...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biochemistry
سال: 2020
ISSN: 0300-8177,1573-4919
DOI: 10.1007/s11010-020-03802-x